Sinclair Method Studies
Published on: 11/06/2025
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
Endorphin Addiction: The Link Between Alcohol and the Brain’s Pleasure System
Published on: 06/03/2025
Endorphins are natural opioids produced by the brain that regulate pain and pleasure. When alcohol is consumed, it triggers the release of these endorphins in brain areas linked to reward, such as the nucleus accumbens and orbitofrontal cortex. This release creates feelings of euphoria and relaxation, reinforcing the urge to drink.
NeuroscienceThe Sinclair Method (TSM)
